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Electronic address: 2 Department of Computer Science, University of Sheffield, Mappin Street, Sheffield S1 4DP, UK.

1 Sheffield Myeloma Research Team, Department of Oncology, Medical School, University of Sheffield, Beech Hill Road, Sheffield S10 2RX, UK Mellanby Centre for Bone Research, Medical School, University of Sheffield, Beech Hill Road, Sheffield S10 2RX, UK.Electronic address: 9 Sheffield Myeloma Research Team, Department of Oncology, Medical School, University of Sheffield, Beech Hill Road, Sheffield S10 2RX, UK Mellanby Centre for Bone Research, Medical School, University of Sheffield, Beech Hill Road, Sheffield S10 2RX, UK Department of Haematology, Sheffield Teaching Hospitals NHS Foundation Trust, Royal Hallamshire Hospital, Glossop Road, Sheffield S10 2JF, UK Insigneo Institute for In silico Medicine, The Pam Liversige Building, Sir Frederick Mappin Building, University of Sheffield, Mappin Street, Sheffield S1 3JD, UK. Electronic address: 8 Department of Computer Science, University of Sheffield, Mappin Street, Sheffield S1 4DP, UK Insigneo Institute for In silico Medicine, The Pam Liversige Building, Sir Frederick Mappin Building, University of Sheffield, Mappin Street, Sheffield S1 3JD, UK. Electronic address: 7 Mellanby Centre for Bone Research, Medical School, University of Sheffield, Beech Hill Road, Sheffield S10 2RX, UK. Electronic address: 6 Sheffield Myeloma Research Team, Department of Oncology, Medical School, University of Sheffield, Beech Hill Road, Sheffield S10 2RX, UK Mellanby Centre for Bone Research, Medical School, University of Sheffield, Beech Hill Road, Sheffield S10 2RX, UK. Electronic address: 5 Sheffield Myeloma Research Team, Department of Oncology, Medical School, University of Sheffield, Beech Hill Road, Sheffield S10 2RX, UK Mellanby Centre for Bone Research, Medical School, University of Sheffield, Beech Hill Road, Sheffield S10 2RX, UK.

Electronic address: 4 Sheffield Myeloma Research Team, Department of Oncology, Medical School, University of Sheffield, Beech Hill Road, Sheffield S10 2RX, UK Mellanby Centre for Bone Research, Medical School, University of Sheffield, Beech Hill Road, Sheffield S10 2RX, UK. Electronic address: 3 Sheffield Myeloma Research Team, Department of Oncology, Medical School, University of Sheffield, Beech Hill Road, Sheffield S10 2RX, UK Mellanby Centre for Bone Research, Medical School, University of Sheffield, Beech Hill Road, Sheffield S10 2RX, UK.